Product Details
ZEPBOUND® Prefilled Syringe (Tirzepatide) 10mg/.5ml
Manufacturer: Eli Lily and Company
MFG#: 00002-2471-80
PID: 639222
1/EA
$ *.**
In StockAdditional Information
| Brand Name | ZEPBOUND® |
| Generic Name | Tirzepatide |
| Dosage Form | Prefilled, single-dose syringe (subcutaneous injection) |
| Strength | 10 mg / 0.5 mL |
| Pharmacological Class | Dual Glucose-dependent Insulinotropic Polypeptide (GIP) and GLP-1 (Glucagon-like Peptide-1) Receptor Agonist |
| Indication | Chronic weight management in adults with obesity (BMI =30 kg/m²) or overweight (BMI =27 kg/m²) with at least one weight-related comorbidity (e.g., hypertension, type 2 diabetes, dyslipidemia, obstructive sleep apnea, cardiovascular disease). |
| Key Mechanism of Action | Functions as a dual agonist, activating both the GIP and GLP-1 receptors. This action stimulates glucose-dependent insulin secretion, suppresses glucagon secretion, slows gastric emptying, and reduces appetite via central nervous system pathways. |
| Storage | Refrigerate at 2°C to 8°C (36°F to 46°F). Do not freeze. If needed, the prefilled syringe may be stored at room temperature up to 30°C (86°F) for up to 21 days; do not return to refrigeration after storage at room temperature. |
| Contraindications | • Personal or family history of medullary thyroid carcinoma (MTC). • Patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). • Known serious hypersensitivity to tirzepatide or any of the excipients. |
| Warnings & Precautions | • Risk of Thyroid C-Cell Tumors: Has been observed in rodent studies. Relevance to humans unknown. Monitor patients for signs and symptoms of thyroid tumors. • Pancreatitis: Has been reported. Discontinue promptly if pancreatitis is suspected. • Hypoglycemia: May occur when used concomitantly with insulin secretagogues (e.g., sulfonylureas) or insulin. Consider lowering the dose of these medications. • Acute Kidney Injury: Monitor renal function in patients with renal impairment reporting severe adverse gastrointestinal reactions. • Severe Gastrointestinal Disease: Use may be associated with gastrointestinal adverse reactions, sometimes severe. |
| Common Adverse Reactions | Nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection site reactions, fatigue, hypersensitivity reactions, eructation, hair loss, gastroesophageal reflux disease. |
| Drug Interactions | • May delay gastric emptying and impact the absorption of concomitantly administered oral medications. • Use with insulin or insulin secretagogues increases the risk of hypoglycemia. |
| Patient Counseling Points | • Instruct on proper injection technique and the importance of dose titration to manage GI side effects. • Advise patients to report symptoms of pancreatitis (persistent severe abdominal pain), thyroid tumors (lump in neck, dysphagia), or hypoglycemia. • Counsel on the importance of a reduced-calorie diet and increased physical activity. |
Description
ZEPBOUND® (tirzepatide) 10 mg/0.5 mL prefilled syringe is a once-weekly, dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 (glucagon-like peptide-1) receptor agonist indicated for chronic weight management in adults with obesity (BMI =30 kg/m²) or overweight (BMI =27 kg/m²) with at least one weight-related comorbidity, to be used adjunctively with a reduced-calorie diet and increased physical activity. Its novel mechanism synergistically activates both GIP and GLP-1 receptors, enhancing insulin secretion, suppressing glucagon, delaying gastric emptying, and promoting satiety within the hypothalamus, which collectively drive significant and sustained weight loss. The 10 mg dose represents a key maintenance option following a structured titration schedule from a 2.5 mg starting dose, designed to optimize gastrointestinal tolerability while achieving therapeutic efficacy.
Frequently Asked Questions (FAQs)
The cost of ZEPBOUND® Prefilled Syringe (Tirzepatide) 10mg/.5ml is $$0.00
ZEPBOUND® Prefilled Syringe (Tirzepatide) 10mg/.5ml is manufactured by Eli Lily and Company.
You can purchase ZEPBOUND® Prefilled Syringe (Tirzepatide) 10mg/.5ml on our website at https://preview_supplies.pipelinemedical.com/product/detail/zepbound-prefilled-syringe-tirzepatide-10mg-5ml-639222